Understanding NMT: Unraveling A Potential Drug Target (P34708)

Target Name: Glycylpeptide N-tetradecanoyltransferase

NCBI ID: P34708

Glycylpeptide N-tetradecanoyltransferase

Other Name(s): NMT | N-myristoyltransferase (NMT) | Peptide N-myristoyltransferase | N-Myristoyltransferase

Understanding NMT: Unraveling A Potential Drug Target

Glycylpeptide N-tetradecanoyltransferase (NMT) is a protein that is expressed in various tissues throughout the body, including the brain, heart, kidneys, and gastrointestinal tract. It is a member of the superfamily of N-acyltransferases (NATs), which are a group of enzymes that transfer the N-acetyl group from a cysteine residue to another molecule.

NMT is involved in the catabolism of glycylpeptides, which are a type of lipid molecule that is derived from the amino acids glycine and leucine. These molecules are found in a variety of tissues throughout the body, including the brain, and are thought to play important roles in various physiological processes, including energy metabolism and stress response.

In addition to its role in the catabolism of glycylpeptides, NMT is also involved in the regulation of cellular processes that are related to the stress response. Specifically, it has been shown to play a role in the detoxification of oxidative stress, which can be caused by a variety of factors, including exercise, UV radiation, and certain medications.

Despite its involvement in a number of important cellular processes, NMT is not well understood, and there is a need for further research to fully understand its function. One reason for this lack of understanding is that the primary function of NMT is not well understood, and there is limited research on the underlying molecular mechanisms that are involved in its activity.

In recent years, researchers have made some progress in the study of NMT, and have identified a number of potential drug targets that could be targeted by small molecules. For example, studies have shown that inhibitors of NMT have the potential to protect against oxidative stress and to improve cellular energy metabolism. In addition, there is evidence to suggest that NMT may be involved in the regulation of the stress response, and that it may play a role in the development of certain diseases, such as cancer.

Overall, while there is still much to be learned about NMT, its potential as a drug target or biomarker is significant. Further research is needed to fully understand its function and to develop effective therapies that can be used to treat a variety of conditions.

Protein Name: Glycylpeptide N-tetradecanoyltransferase (nonspecified Subtype)

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